Association between <i>HLA‐B</i> and <i>HLA‐DRB1</i> polymorphisms and systemic lupus erythematosus in Han population in China

We explored the association between HLA-B and HLA-DRB1 polymorphisms reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population Yunnan, China. Methods There were 295 patients 265 healthy control subjects (HCs) enrolled study. Clinical data blood samples collected from patients. The genotypes detected SLE HCs. Results A total 74 on loci determined 288 as well 57 results showed was associated with HLA-B*40:01 HLA-DRB1*08:03 alleles, HLA-B*46:01, HLA-DRB1*12:02, DRB1*04:03, DRB1*14:01, DRB1*04:06, DRB1*11:01 alleles less likely to appear Additionally, HLA-B*07:02 B*40:06 disease activity. HLA-DRB1*03:01, DRB1*13:02, DRB1*12:01 proteinuria. Furthermore, HLA-B*51:01, B*13:02, B*38:02, B*35:01, HLA-DRB1*15:02, DRB1*15:04, DRB1*15:01, DRB1*08:03 correlated inflammatory factors immune dysfunction. HLA-B*15:25 related production multiple antibodies. HLA-DRB1*12:02 might be a protective factor for pancytopenia. haplotype HLA-B*40:01/DRB1*08:03 linked SLE. Conclusion Yunnan province HLA-B*40:01/DRB1*08:03. Several inflammation, disorders, organ involvement Those potential genetic markers